Decarbonizing medical gases: the challenge of nitrous oxide (N2O)

Interview with Jean-Christophe Poirier, Head Pharmacist and Director of Safety and Quality of Operations and Health Products and CSR for the medical gas activity in France.

Published on October 07, 2025

6 minutes

Nitrous oxide (N2O) is the main source of greenhouse gas (GHG) emissions among the medical gases used in operating rooms. While its global warming potential is nearly 300 times greater than that of CO2, its network distribution in hospitals leads to significant gas losses. At the heart of our “Always there” ambition and its pillar dedicated to carbon neutrality by 2050, Air Liquide Healthcare is committed to changing the distribution of medical nitrous oxide by supporting hospitals in opting for mobile cylinders. This solution reduces the carbon footprint of hospitals while meeting the current limited demand for N2O medical gas.
Let's ask Jean-Christophe Poirier our questions.

 

How can we reduce the carbon footprint of hospitals?

JCP: Every sector of activity is called upon to reduce its carbon footprint, and the healthcare sector, including hospitals in particular, is no exception. The healthcare sector's climate footprint accounts for 4.4% of global net emissions, equivalent to 2 gigatons of carbon dioxide1. If the healthcare sector were a country, it would be the fifth largest emitter on the planet1. In France, 38% of greenhouse gas emissions from the healthcare sector are generated by hospitals2. Medicines and medical gases are included in this percentage. Air Liquide Healthcare's approach has been to engage in discussions with healthcare professionals to define priorities for action. Very quickly, our attention turned to medical nitrous oxide, or N2O. Although rarely employed, medical N2O is used in anesthesia for operating rooms, mainly in pediatrics.

Why is it necessary to decarbonize medical nitrous oxide N2O? Is this really a key issue in combating global warming?

  • Medical nitrous oxide less than 1 % volume

    of total medical gases

  • Medical nitrous oxide 75 % Carbon footprint

    of total medical gases

JCP: According to hospitals, medical nitrous oxide accounts for a minimal proportion of volumes (less than 1%), but it contributes significantly to the carbon footprint of medical gases (>75%) in most cases. This imbalance is explained by its powerful global warming potential, which is 273 times greater than that of carbon dioxide (CO2) over a 100-year period3. In other words, 1 kg of N2O used is equivalent to 273 kg of CO2. Furthermore, medical N2O is not metabolized by the body after administration, so the gas exhaled by the patient also has an impact. You can see how medical N2O is a powerful lever for reducing carbon footprints, and our work with hospital healthcare professionals will therefore focus on reducing its volumes.

A rapid and significant reduction in carbon footprint

In practice, medical nitrous oxide is distributed in hospitals through a dedicated network, with wall outlets allowing the gas to be released in the operating rooms. The major challenge lies in gas losses associated with its distribution through the network. Studies conducted in the United Kingdom4 and the United States5 have revealed that medical N2O distribution networks in hospitals can have a loss rate of over 90%! Micro losses in the network ultimately represent a very significant volume compared to the volume actually used for the patient. Taking action on medical nitrous oxide distribution by limiting losses therefore enables hospitals to massively reduce their greenhouse gas emissions.

How can medical N2O be decarbonized? What implementation solutions does Air Liquide Healthcare offer?

JCP: Air Liquide Healthcare is aligning itself with the recommendations of the French Society of Anesthesia and Intensive Care (SFAR) by assisting hospitals in implementing the shutdown of their medical N2O distribution network and switching to the use of cylinders for residual uses.

Objective: volume consumed = useful volume

In concrete terms, we have developed a number of pilot projects with partner hospitals, and based on the successful experience of these pilots, we have rolled out this approach to other establishments. With the pediatric department at Toulouse University Hospital, we began by confirming the hypothesis of reducing useful medical NO2 consumption by using cylinders rather than network distribution. Estimates made in this pediatric department show a very significant saving in medical nitrous oxide. It is our responsibility to take a proactive approach to the environment while responding to current medical needs. Air Liquide Healthcare is also involved in a research project aimed at destroying the residual medical N2O contained in cylinders.

What other projects is Air Liquide Healthcare working on to decarbonize medical gases and and help build a more sustainable healthcare system?

JCP: The decarbonization of medical gases is not limited to N2O, even if, as we saw earlier, it is a gas that needs to be addressed as a priority. For medical gases in France, our strategy for carbon neutrality by 2050 is also based on other levers:

  • Optimizing the use of MEOPA (equimolar mixture of oxygen and nitrous oxide) by recommending specific equipment to rationalize gas consumption.
  • Supplying low-carbon gases: medical liquid oxygen and medical liquid nitrogen are the most commonly used gases in hospitals and therefore contribute to greenhouse gas emissions from medical gases. Their main impact results from the emission factor of the electricity used to produce them. Thus, using 100% renewable electricity can reduce the carbon footprint of oxygen by more than 70%6. Air Liquide Healthcare therefore follows a policy of purchasing electricity produced from renewable energy sources and offers hospitals the ECO ORIGINTM solution.

Key points to remember:

  • The healthcare sector, and hospitals in particular, must contribute to the reduction of greenhouse gases.
  • Medical nitrous oxide (N2O) is a powerful greenhouse gas, accounting for 75% of the carbon footprint of medical gases despite its very low volume, less than 1%.
  • Massive losses are observed in medical N2O distribution networks, making it a priority target for action.
  • The solution is to stop network distribution and replace it with cylinders.
  • Pilot projects have shown massive reductions in medical N2O emissions with this strategy, exceeding 90%!
  • Beyond medical N2O, Air Liquide Healthcare's approach to carbon neutrality includes optimizing the use of other gases (MEOPA) and supplying medical gases (oxygen and nitrogen) produced with low carbon emissions, thanks to the use of 100% renewable electricity.
Based on concrete projects and measurable results, Air Liquide Healthcare supports hospitals in decarbonizing medical gases. Taking action on medical gases is an effective way for hospitals to reduce their carbon footprint.
References
2. The Shift Project. Décarboner la santé pour soigner durablement. Rapport final V2. Avril 2023.
6. Estimated Carbon footprint reduction decrease level depending on current carbon footprint per geography and Eco origin target level Certified by an independent organization, in compliance with international ISO standards 14021/ 14067